VITAMIN B12 // ABSORPTION // TEST // FUNCTION ~ Medical diseases and trems ,symptoms causes TREATMENT

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VITAMIN B12 // ABSORPTION // TEST // FUNCTION



VITAMIN B12

     * It also known as cyanocobalamin / Anti pernicious anemia factor.

     * Discovered by karl august folkers and shoaib in 1948 .

     * This is the last discovered vitamin .

     * Normal serum B12 level is 200-900 pg/ml .

     * It is a cobalt containing vitamin .

     * It synthesis by large intestinal flora lactobacillus .

     * It store in liver [4-5 mg] which sufficient for 2-3 year.

ABSORPTION

          Absorption of vitamin b12 in terminal part of ilium in the presence of intrinsic factor which secret from gastric parietal cells of stomach .

TEST 

        For vitamin B12 absorption test is schilling test.

FUNCTION 

    ** Essential for maturation of RBC in bone marrow .

     * Help in formation of WBC ,AND Platelet .

    ** Help in synthesis of DNA .

      * Act as co enzyme in synthesis of methionine .

     * Help in myelin sheath of neuron .

SOURCES

   * Colonic flora .

   * Vitamin B12 not found in plant sources or more chances of deficiency in strict vegetarian or person who depend upon vegan diet .

  * Animal diet sources →  Milk, meat ,fish ,egg ,cord liver oil [good sources].

Recommended Dietary Allowance

  * Infant 0.2 mcg/day.

  * child 0.5 to 1 mcg/day .

  * Early adolescent  13-15 year 0.5 to 1mcg/day.

  * Adult male and female 1 mcg/day.

  * Pregnancy 4 mcg /day.

  * Lactation 3 mcg /day.

DEFICIENCY

   * Pernicious anemia.


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