Diabetes Insipidus || cause || Types of Diabetes insipidus || sign and symptoms || Diagnosis || Management ~ Medical diseases and trems ,symptoms causes TREATMENT

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Diabetes Insipidus || cause || Types of Diabetes insipidus || sign and symptoms || Diagnosis || Management



 Diabetes Insipidus

                                 Decrease secretion or functioning of the ADH hormone is called diabetes insipidus.

 Cause of D.I.-

                         * Trauma 

                         * Suppressing  tumor

                         * Resistance of receptor

                         * Behavioural problem

  Types of Diabetes Insipidus

            1. Cranial Diabetes Insipidus -

                        *  In this condition the abnormality occur in Hypothalamus or posterior pituitary so the                               production and release of the ADH hormone become decrease.

                        * Serum ADH level - Decrease.

           2. Nephrogenic Diabetes Insipidus

                       *   In this condition the ADH receptor become resistance .

                       *  The serum ADH level become Increase due to positive feedback mechanism .

          3. Psychogenic Diabetes Insipidus

                        * It is also known as polydipsic diabetes Insipidus in this condition the individual drink excessive water due to psychological problem it occur in schizophrenia  patient and female 

                        * Serum ADH level normal.

 Assessment finding 

                       * Polyuria 

                       * Polydipsia 

                       * Hypovolemia 

                      * Hypotension 

                      *  Dehydration  

                      * Shock

                      * Blood osmolarity increase 

                      * Urine osmolarity decrease 

                      * Hyper natremia

                      * Excessive water loss 

                      * Hypokalemia

 Diagnosis

                       Water deprivation test 

                               In this test the water intake is stope for some time and then amount of urine is                                     assessed . If water intake is stope but polyuria occur , it indicate Diabetes insipidus.

 Management

                        The treatment depend on the types and cause of DI

     A.   For Cranial DI 

                                The HRT should be provided. The synthetic hormone available is Desmopressin , it                             also known as DDAVP { 1 - de amino - 8- D- arginine vasopressin }.

    B. For nephrotic DI

                              In this condition the drug are administer which stimulate the activity of ADH                                          receptor. Example - Carbamazepine and chlorpropamide

    C. For Psychogenic DI     

                               Behavioural modification therapy should be provided.

 

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